Cancer Biology Faculty
Track Leader-Larry Suva, Ph.D.

Martin Cannon, Ph.D. (Microbiology and Immunology) Web profile
Dendritic cell immunotherapy of cancer
mjcannon@uams.edu

Timothy Chambers, Ph.D. (Biochemistry and Molecular Biology) Web profile
Cancer chemotherapy, apoptosis, cell signaling, cell cycle regulation
ChambersTimothyC@uams.edu

Amanda Charlesworth, Ph.D.(Neurobiology and Developmental Sciences) Web profile
Molecular mechanisms that regulate mRNA translation in early development.
charlesworthamanda@uams.edu

Craig Cooney, Ph.D. (Biochemistry and Molecular Biology) Web profile
We study maternal effects in mice, aging in mice and the epigenetics of human cancer. Our research with maternal diets or alcohol focuses on lasting changes in mouse offspring. In adult mice we study the causes and effects of aging, especially how changes in epigenetics affect lifespan. Our research on cancer includes study of human tumors and tissue culture cells. All of these studies include analysis and/or modification of epigenetic mechanisms (DNA methylation and histone modification). Our long term research aims are the improvement of maternal nutrition, the prevention of birth defects, nontoxic therapies for cancer treatment and prevention, and improved longevity in mice and humans.
cooneycraiga@uams.edu

Mari Davidson, Ph.D. (Biochemistry and Molecular Biology) Web profile
DavidsonMariK@uams.edu

Alan Diekman, Ph.D. (Biochemistry and Molecular Biology) Web profile
DiekmanAlan@uams.edu

Joshua Epstein, D.Sc. (Internal Medicine/Myeloma Institute for Research and Therapy) Web profile
jepstein@uams.edu

Dana Gaddy, Ph.D. (Physiology and Biophysics) Web profile
Our laboratory focuses on the endocrine, cellular and molecular mechanisms that govern the maintenance of the musculoskeletal system, with particular focus on the normal and pathophysiological changes associated with age, disuse, menopause, and metastatic disease.
gaddydana@uams.edu

Randy Haun, Ph.D. (Pathology) Web profile
Our laboratory is interested in 1) identifying proteases that are expressed in pancreatic cancer and understanding the roles they play during tumor invasion and metastasis, 2) characterizing signal transduction pathways that lead to chemoresistance in patients with pancreatic cancer, and 3) characterizing serum biomarkers that may be used for early detection of this devastating disease.
HaunRandyS@uams.edu

Masahiro Higuchi, Ph.D. (Biochemistry and Molecular Biology) Web profile
Roles of mitochondria and mitochondrial DNA on cancer progression and aging
Mhiguchi@uams.edu

Thomas Kelly, Ph.D. (Pathology) Web profile
Proteases and heparanases in cancer metastasis
KellyThomasJ@uams.edu

Angus MacNicol, Ph.D. (Neurobiology and Developmental Sciences) Web profile
Cell cycle control, gene expression, early vertebrate development, signal transduction
macnicolangus@uams.edu

Grover Paul Miller, Ph.D. (Biochemistry and Molecular Biology) Web profile
The focus of my research is to understand the mechanism underlying the paradoxical ability of cytochrome P450s to suppress and promote carcinogenesis through the metabolism of xenobiotic molecules, e.g. drugs, environmental contaminants, and food additives.
MillerGroverP@uams.edu

Anna Radominska-Pandya, Ph.D. (Biochemistry and Molecular Biology) Web profile
Structure-function relationship studies of human UDP-glucuronosyltransferases (UGTs); Transcriptional regulation of UGTs via environmental pollutants; Role of UGTs in breast cancer and in cancer prevention; and Detoxification of drugs and endogenous compounds
RadominskaAnna@uams.edu

Robert J.S. Reis, D. Phil. (Geriatrics) Web profile
Genetics of longevity; role of homologous recombination in oncogenesis and cancer progression.
rjsr@uams.edu

Victor Samokyszyn, Ph.D. (Pharmacology and Toxicology) Web profile
SamokyszynVictorM@uams.edu

Frank A. Simmen, Ph.D. (Physiology and Biophysics) Web profile
Our laboratory is studying novel molecular aspects of intestinal gene expression and small intestine and colon tumorigenesis.
simmenfranka@uams.edu

Larry Suva, Ph.D. (Physiology and Biophysics) Web profile
Research interests are broad, but primarily associated with understanding the skeletal consequences of disease.
suvalarryj@uams.edu

Jerry Ware, Ph.D. (Physiology and Biophysics) Web profile
Our laboratory has a long-standing interest in the role of circulating platelets in disease processes. Recent studies have found a platelet adhesion receptor that is critical for normal blood coagulation also supports metastasis of tumor cells. Mouse models deficient in this platelet receptor have yielded results confirming the relevance of platelets in tumor metastasis. Ongoing studies will further define the molecular mechanism supporting these processes and may identify new therapeutic strategies for preventing the spread of malignant disease.
jware@uams.edu